Bio Diane Keogh has extensive Healthcare IT experience including academic medical centers, community and specialty hospitals, provider networks, industry, and biomedical research with a major focus on cost effectively utilizing technology in alignment with corporate healthcare and academic research goals. Diane spent the past 25 years as an executive member of the IS management team at Partners Healthcare in Boston. During that time she held the following positions: CIO of a community hospital Corporate Director of Enterprise Services responsible for clinical data integration, non-acute services, quality, mental health and research IT. Corporate Director of Research Computing responsible for building IT services to support clinical research, basic research, research administrative systems, and genomic IT systems. Executive Director of Reporting and Analytics responsible for the enterprise implementation of the Epic system with a primary focus on operational and analytical reporting and data extracts for the clinical and research enterprise. Diane currently holds the position of Managing Director of the i2b2 Foundation. Title: i2b2 Foundation/i2b2 platform: Integrating Clinical Data with Translational Research for Precision Medicine Abstract In 1999, the Research Patient Data Repository (RPDR) was created at Partners HealthCare System, based on evaluations of queries against the existing EMR databases and other query‐generating tools. The RPDP is a research data warehouse with medical record information from multiple hospital and outpatient systems at Partners. The RPDR includes both data collected into the database and a tool for querying data from the repository. This tool allows research investigators to create cohorts of patients that meet specific criteria, in order to assess the availability of patients and patient data for studies. Once a cohort is defined and queried, patient identifiers and complete electronic medical records can be obtained according to institutional review board (IRB) approval. The RPDR was one of the first enterprise-wide data warehouses designed and maintained to specifically support the needs of the clinical researcher and was used as the model to develop i2b2. Integrating Informatics and Biology at the Bedside (i2b2) was funded in 2004 as one of four initial National Centers for Biomedical Computing (NCBC) grants. The purpose of the i2b2 project was to create open source software that could be used in research institutions across the nation to query data extracted from electronic medical records, either for identification of research cohorts or to discover potential clinical knowledge from observational studies using the data. In this way, i2b2 facilitates the use of a research data infrastructure, based on the design and lessons learned from RPDR. i2b2 has been successfully implemented at over 140 research institutions or academic medical centers (including over half of the CTSA networks) throughout the country, and an additional 50+ organizations internationally. It has also been adopted by industry. It is arguably the most widely‐used clinical research data infrastructure based on electronic health records in the world. The i2b2 Foundation was created to continue the support and development for the i2b2 platform for its many members. The combination of i2b2 and tranSMART creates a powerful distribution query system of specialized data with statistical analysis tools to support discoveries in clinical research.